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3 Weight Loss Injections for Sustainable Results

weight loss injections

Semaglutide

In Stock
As low as $197/Mo
  • Favorite for Weight Loss Support
  • Patients report low hunger
NAD+ Vial

Obesity and weight-related health conditions are among the biggest challenges facing patients today, and for many, diet and exercise alone are not enough to achieve lasting results. Advances in medicine have introduced a new class of injectable treatments called GLP-1 receptor agonists, which mimic the body’s natural hormones to regulate appetite, slow digestion, and improve blood sugar control.

Among the most widely used options are liraglutide, semaglutide, and tirzepatide—three prescription medications that have shown impressive outcomes for weight management and metabolic health. This article explores how each of these weight loss injections works, their unique benefits, potential side effects, and which option may be the most effective depending on individual needs.

Liraglutide: Setting the Standard in Weight Loss Injections

Liraglutide is in a class of medications called glucagon-like peptide-1 (GLP-1) receptor agonists. Medications in this class act like your body’s naturally produced GLP-1 hormone. This hormone suppresses your appetite, increases satiety, and slows stomach emptying, so you feel full longer.

GLP-1 hormone also binds to receptors in the pancreas and stimulates insulin release. Insulin lowers glucose in the bloodstream by moving it into body cells, where it can be used for energy. Liraglutide treats diabetes and obesity.

Semaglutide: A Game-Changer in Weight Loss Injections

Like liraglutide, semaglutide is a GLP-1 receptor agonist. But its chemical composition means that it lasts longer in the body, so it can be taken once per week instead of daily.

Semaglutide slows stomach emptying so you feel full longer, increases insulin secretion from the pancreas to reduce abnormally high blood sugar, and signals your brain that you are satisfied and no longer hungry.

Tirzepatide: A Dual Receptor Agonist in Weight Loss Injections

Tirzepatide is a novel dual-receptor agonist that activates both the GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors. By targeting both pathways, tirzepatide offers a synergistic effect on weight loss and blood sugar control. Its once-weekly dosing schedule makes it a convenient option for patients seeking long-term weight management.

Tirzepatide reduces blood sugar levels, improves insulin sensitivity, improves blood lipid levels, curbs hunger, increases satiety, and helps you feel full longer.

Is a GLP-1 Medication Right for You?
See if a GLP-1 like Semaglutide or Tirzepatide is a fit for your health goals.
NAD+ Vial

Comparing liraglutide vs semaglutide vs tirzepatide weight loss injections

Semaglutide and liraglutide are very similar medications, with the most obvious difference being their dosage frequency. Tirzepatide is a GLP-1 receptor agonist, like semaglutide and liraglutide, but it is also a GIP receptor agonist. Targeting two receptors leads to even greater weight loss.

Weight loss injections: Benefits

All three weight loss injections are GLP-1 receptor agonists and, therefore, can have the following benefits:

  • Stimulates insulin release
  • Inhibits glucagon release
  • Slows stomach emptying
  • Suppresses appetite
  • Increases satiety after eating
  • Decreases abdominal fat
  • Decreases blood pressure
  • Reduces LDL (bad) cholesterol
  • Increases HDL (good) cholesterol
  • Decreases triglycerides
  • Decreases blood sugar

Safety Profile

Both semaglutide and tirzepatide are generally well-tolerated, with gastrointestinal events being the most common adverse side effects. Nausea and diarrhea are the most frequently gastrointestinal side effects.

The most common side effects include:

  • Nausea
  • Diarrhea
  • Vomiting
  • Constipation
  • Indigestion
  • Stomach pain

Potential serious adverse effects associated with GLP-1 anti-obesity medications include:

  • Diabetic retinopathy in people with type 2 diabetes
  • Gallbladder disease
  • Acute kidney injury
  • Hypersensitivity or allergic reactions
  • Thyroid cancer
  • Injection site reactions
  • Faster heart rate
  • Low blood sugar
  • Suicidal behavior or ideation
  • Inflammation of the pancreas
  • Intestinal blockage

All the GLP-1 drugs are fairly new, so this list may increase with increased drug use across populations.

Semaglutide

In Stock
As low as $197/Mo
  • Favorite for Weight Loss Support
  • Patients report low hunger
NAD+ Vial

Conclusion: What is the most effective weight loss injection?

Liraglutide, semaglutide, and tirzepatide are prescription weight-loss medications. All three are anti-obesity medications that may also reduce the risk of cardiovascular disease.

All three medications can cause significant gastrointestinal side effects that improve over time. They are all expensive medications. They are not appropriate for all people, so it is essential to talk with a board-certified, licensed healthcare provider who has experience using these medications to learn more about the risk-versus-benefit profile of using these medications to treat obesity.

If you evaluate the medications in terms of their demonstrated weight-loss potential, then tirzepatide comes out as the winner.

From The Expert: Maybell Nieves, M.D.

Weight loss injections, can be effective tools for sustainable weight management when combined with lifestyle changes. These medications work by mimicking natural hormones that regulate appetite and blood sugar, leading to reduced food intake and improved satiety. Patients typically experience a 15-20% reduction in body weight over 68 weeks with semaglutide and even more with tirzepatide. Common side effects, affecting about 1 in 3 users, include nausea, vomiting, diarrhea, or constipation, which often improve over time. It’s crucial to discuss your full medical history with your doctor, especially if you have a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), as these are contraindications for these medications. Seek immediate medical attention if you experience severe abdominal pain, as this could indicate pancreatitis or gallbladder issues. In general the best weight loss effects have been seen with tirzepatide.

Written by

Leann Poston M.D.
Leann Poston M.D.
Licensed Physician and Medical Content Reviewer
Dr. Leann Poston is a licensed physician in the state of Ohio who holds an M.B.A. and an M. Ed. She is a full-time medical communications writer and educator who writes and researches for Invigor Medical. Dr. Poston lives in the Midwest with her family. She enjoys traveling and hiking. She is an avid technology aficionado and loves trying new things.

Medically Reviewed By

Maybell Nieves, M.D.
Maybell Nieves, M.D.
General Surgery / Medical Reviewer
Dr. Maybell Nieves is an internationally trained general and breast surgeon—graduate of the European Oncology Institute and University of Milan—who serves as academic coordinator and breast surgeon at the Universitary Hospital of Caracas, manages high-volume oncologic care and fellow training, pioneered a breast surgery unit, and partners with nonprofits on early detection and awareness.
Medical Review Process
Every article on Invigor Medical is reviewed by licensed medical professionals to ensure accuracy, clarity, and clinical relevance. Our editorial team works closely with practitioners to verify that content reflects current research, guidelines, and best practices.
Disclaimer and Medical Information
The content provided in this article is for informational and educational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always consult with a licensed healthcare provider regarding any medical concerns, conditions, or treatments. Do not disregard medical advice or delay seeking it because of something you have read on tryinvigor.com.

Invigor Medical does not offer emergency medical care. If you are experiencing a medical emergency, call 911 or go to the nearest emergency room immediately.

Medical treatments discussed on this site may not be appropriate for everyone. All medications require a prescription from a licensed healthcare provider following an appropriate telehealth consultation, and treatment decisions should be made on an individual basis.
Leann Poston M.D.
Leann Poston M.D.
Licensed Physician and Medical Content Reviewer
Dr. Leann Poston is a licensed physician in the state of Ohio who holds an M.B.A. and an M. Ed. She is a full-time medical communications writer and educator who writes and researches for Invigor Medical. Dr. Poston lives in the Midwest with her family. She enjoys traveling and hiking. She is an avid technology aficionado and loves trying new things.

Medication Disclaimer

Important Safety Information

Maybell Nieves, M.D.
Maybell Nieves, M.D.
General Surgery / Medical Reviewer
Dr. Maybell Nieves is an internationally trained general and breast surgeon—graduate of the European Oncology Institute and University of Milan—who serves as academic coordinator and breast surgeon at the Universitary Hospital of Caracas, manages high-volume oncologic care and fellow training, pioneered a breast surgery unit, and partners with nonprofits on early detection and awareness.