One of the most frequently asked questions on the Internet today regarding the erectile dysfunction medication Trimix is, “How much does Trimix cost?” It’s a reasonable question – after all, most healthcare-related things today seem to cost an (almost literal) arm and a leg. While it’s not necessarily easy or straightforward to provide a simple answer to that question that is true for everyone, we’ll do our best to explain the basics of Trimix injection costs, and how to buy trimix online in this article.
Many people specifically search for “trimix injection price” when considering this treatment, as understanding the cost per injection is a key concern for those exploring their options.
The good news to start with is that Trimix injections cost less than you might think and are largely cost-competitive with oral ED medications. As Trimix is designed for men who have not had success with oral ED medications and is far more powerful and effective, the fact that it is similar in cost and not several orders of magnitude more expensive is a relief to many men considering it. But there’s more to it than that, so let’s dig a bit deeper.
Table of Contents
Quick Overview Of Trimix
First, it’s useful to recap what exactly Trimix is and how it works. While we’ve covered this topic in much more depth in other articles on our site, a brief refresher can help. Trimix is an injectable medication used as injection therapy to treat ED. It is made out of three medications—phentolamine, papaverine, and alprostadil—compounded together. These three meds work together to help increase blood flow or encourage muscle relaxation, the two mechanisms necessary for a man to achieve and maintain an erection. Alprostadil, one of the active ingredients, is also the active ingredient in FDA-approved brand names such as Caverject and Edex.
To inject Trimix, the medication is administered directly into the penis approximately 20 to 30 minutes before sexual activity. This method is known as a penile injection, and patients inject Trimix directly into the penis. The injection produces erections that typically last one to two hours. Trimix produces erections independent of sexual arousal, unlike some other ED medications. Over several decades of use and numerous studies, it has been found that upwards of 95% of men treated, despite having no luck with oral ED medications, were able to achieve satisfactory results with Trimix. Trimix is often used when other ED medications have not worked.
Because Trimix is a powerful injectable medication, it is only available with a prescription in the United States and many other jurisdictions. Prescriptions are required, and healthcare providers prescribe Trimix after evaluating the patient. Treatment typically begins with the smallest dosage likely to be effective to ensure safety and efficacy. This injection therapy is used to treat ED in men who do not respond to oral medications.

How Trimix Works
Trimix injections are a powerful option for men suffering from erectile dysfunction, especially when other ED treatments have not provided the desired results. This compounded medication combines three active ingredients—alprostadil, papaverine, and phentolamine—to treat erectile dysfunction by directly increasing blood flow to the penis. Each of these medications works together to relax the blood vessels and smooth muscle tissue in the penis, making it easier for blood to flow in and create an erection.
Unlike oral medications, Trimix is administered as an injection directly into the penis, typically about 20 to 30 minutes before sexual intercourse. The medication is prescribed by a licensed healthcare provider, often off label, since the combination itself is not FDA approved, even though the individual components are. Once injected, Trimix helps men achieve and maintain an erection sufficient for sexual activity by enhancing the flow to the penis and supporting the physiological processes necessary for an erection. This makes Trimix a valuable treatment option for men who need a more effective solution for ED.
Why There’s No Single Answer To “How Much Does Trimix Cost?”
It may seem like there should be a simple, single answer to, “How much do Trimix injections cost?” Of course, there is variation depending on where you buy it, like any medication or really anything you purchase. Trimix costs can fluctuate, and trimix injection prices may differ between pharmacies. The cost per dose also depends on how many injections one vial provides and how long a vial lasts for most patients, which is typically two to three months. But there are also other factors that can drastically alter the price per injection on a net basis. The most influential of these factors is the dose of Trimix that is needed for a particular patient. Most insurance companies do not cover compounded medications like Trimix, so patients should consider this when evaluating their options. Some patients may consider other therapies if Trimix is not suitable or cost-effective.
Dosage
Trimix is typically sold in vials of a set volume – most often 5 mL or 10 mL. Patients use a fraction of this each time they take a Trimix dose, based on the dosing schedule prescribed by their doctor. Since everyone responds differently, most practitioners start new patients out on a relatively low dose, allowing for gradual increases until the desired results are achieved. It’s always best to use the lowest effective dose, as the risk of side effects increases at higher doses.
Therefore, the final, stable dose that Patient A might be using can be quite different from Patient B. Two patients using an identical volume or vial of Trimix may get a vastly different number of doses out of it. Since that makes up the denominator in any equation relating to cost per dose, there’s obviously a great deal of individual variability in answering, “How much do Trimix injections cost?”

Other Factors
Other factors can also play a role in the final cost of Trimix injections. The medication has a limited shelf life in the refrigerator after it is first opened (normally stored in the freezer until opening and then stored in the refrigerator for subsequent dosing). It lasts only about 3 months in the refrigerator. So, if only used very infrequently, patients can end up with wastage of a certain amount of the medication. The net effect would be an increase in each injection’s effective cost since some portion of the total vial would be wasted.
Comparison to FDA Approved Medications
When considering ED treatment options, many patients compare Trimix injections to FDA-approved oral ED medications like Viagra, Cialis, and Levitra. These oral medications are known as phosphodiesterase type 5 (PDE5) inhibitors and are typically the first line of treatment for erectile dysfunction. Oral ED medications require sexual arousal to be effective and usually take between 15 and 60 minutes to work, depending on the specific drug and individual patient response.
Trimix injections, on the other hand, can produce an erection within 5 to 20 minutes, regardless of sexual arousal. This makes Trimix a preferred choice for men who have not responded well to oral medications or who need a more reliable solution. However, it’s important to note that Trimix is not FDA approved as a combination medication, and its use is considered off label. The efficacy and safety of Trimix injections may vary from patient to patient, so it’s essential to consult a healthcare provider to determine which ED treatment is best suited to your individual needs and medical history.
About Insurance Coverage For Trimix
One topic that often comes up in relation to discussing, “How much do Trimix injections cost?” is insurance. Most insurance companies do not cover compounded medications like Trimix, but may cover FDA-approved brand names such as Caverject and Edex. Since Trimix is a compounded medication, it is not covered within the vast majority of insurance programs in the United States. That means that, even with insurance, the cost paid for Trimix tends to fall mostly on the patient, and tends to be about the same as those who don’t have insurance. On the upside, that means that the price is maintained at a relatively accessible level – not thousands of dollars per dose like some more exotic drugs.
Whether you fill a prescription through your doctor at your local pharmacy, you will be paying about the same for Trimix. Every pharmacy has its own pricing structure to cover overhead and other expenses, of course, but generally speaking, prices will be within the same range as one another. Prescriptions for other ED medications, such as oral PDE5 inhibitors or FDA-approved injectables like Caverject, may be treated differently by insurance, and coverage can vary. When insurance does cover Trimix, it usually only does so for clinical injections (e.g., administered by a nurse or doctor in their office or another facility), which is not the ideal use case for Trimix, nor suitable for the vast majority of patients looking to use it for sexual activity. Compared to Trimix, insurance coverage for other ED medications is often broader, especially for FDA-approved options.

Trimix Injection Procedure
Administering Trimix injections is a straightforward process, but it’s important for patients to be properly trained by a healthcare provider before starting treatment at home. The injection is given directly into the side of the penis, and patients are instructed to alternate sides with each use to minimize the risk of tissue damage. Before injecting, patients should carefully follow the instructions provided by their healthcare provider to ensure correct technique and dosage.
After the injection, gentle pressure should be applied to the injection site to reduce the risk of bleeding or bruising. Most patients find that the procedure becomes easier with practice, and the medication can be administered discreetly at home prior to sexual activity. It’s crucial not to use Trimix injections more than three times per week, with at least 24 hours between doses, to avoid complications. Following the instructions provided and maintaining open communication with your healthcare provider will help ensure safe and effective use of Trimix.
So, How Much Does Trimix Cost?
OK, you’ve waited long enough! Below, we’ve put together a few examples to answer the question about how much do Trimix injections cost. Please note that for legal reasons, we cannot list the names of our competitors, and have obscured them with “Company X” or similar generic terms. However, rest assured that their pricing (and ours) was accurate as of the day this article was written. However, that may change in the future, so it’s always best to check the latest pricing to buy trimix shots if you are doing any of your own calculations.
Some Notes
Note also that we’ve included two price points to account for the different dosages that a patient may take. One is the typical minimum dose of between 5 and 20 units, and the other is the typical maximum dose of 50 units. Naturally, individual doses may differ significantly between these two ends of the spectrum. The answer to, “How much do Trimix injections cost?” would then need to be recalculated accordingly for that individual.
Further, we’ve normalized the unit pricing to ensure comparison of comparable formulations (as a compounded medication, with 3 active ingredients, they can be combined in many different ratios ). Naturally, a formulation with more active ingredients will cost more than one with smaller quantities of those same ingredients. This ensures that all normalized prices below reflect the same formulation available from Invigor Medical, with the same potency and ratios of ingredients.
Additionally, you have to take into account shipping costs (some companies charge this separately), as well as appointment/consultation costs (again, some companies charge this separately). Where shipping costs are variable based on geographic location, we have used an average of three measurements (New York City, Los Angeles, and Topeka, Kansas).
Price Comparison Table
Invigor Medical | Company X | Company Y | Company Z | |
Vial Size | 5 mL | 5 mL | 5 mL | 5 mL |
Price | $249 | $94.50 | $349 | $249 |
Normalized | $249 | $236.25 | $349 | $273.90 |
Consultation | $5 | $89 | $0 | $29.95 |
Shipping | $18.75 | $22.76 | $19.42 | $14.99 |
Membership | $0 | $49 | $0 | $0 |
Total Cost | $272.75 | $397.01 | $368.42 | $318.84 |
Doses | 10-25 | 10-25 | 10-25 | 10-25 |
Cost Per Dose At | Invigor Medical | Company X | Company Y | Company Z |
20 mcg/Dose | $10.91 | $15.64 | $14.74 | $12.75 |
50 mcg/Dose | $27.28 | $39.70 | $36.84 | $31.89 |
Potential Side Effects
As with any medication, Trimix injections can cause side effects, and it’s important for patients to be aware of the potential risks. Common side effects include changes in blood pressure (either hypotension or hypertension), dizziness, headache, rash or irritation on the penis, and, in some cases, infections or injuries at the injection site. One of the more serious risks is priapism, a prolonged erection lasting more than four hours, which requires immediate medical attention to prevent long-term damage.
Long-term use of Trimix injections can also lead to penile fibrosis, or scarring of the tissue, especially if injections are not rotated properly. To minimize these risks, patients should always follow the instructions provided by their healthcare provider and use the medication exactly as prescribed. If you experience any unusual symptoms or side effects, contact your healthcare provider promptly. It’s also a good idea to discuss the potential risks and benefits of Trimix injections compared to other ED treatments, such as oral medications or other injectable medications, to make the best choice for your health and lifestyle.
Conclusion
When looking to buy Trimix, cost is an important factor to consider. Invigor Medical provides Trimix injections that are competitively priced compared to oral ED medications. Being more effective for those who have not found success with oral options, Trimix comes as a relief for many, balancing affordability and powerful results. For exact pricing and to understand how much your prescription may cost, checking out Invigor Medical’s detailed guide will equip you with the necessary information to make an informed purchase.