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Trimix And Viagra: Can You Use Them Together?

Last Updated: August 23, 2025
Blue pills on a prescription pad.

Erectile dysfunction (ED) is the persistent inability to get and maintain an erection sufficient for satisfactory sexual performance.1 Trimix is an injectable ED medication, and Viagra (sildenafil) is an oral PDE5 inhibitor. Trimix is a combination of three medications—papaverine, alprostadil, and phentolamine—that are injected into the penis to increase blood flow. The success rate for Trimix injection is 53% to 100%.2 But can you use Trimix and Viagra together?

Viagra is a PDE5 inhibitor that stops nitric oxide from breaking down. This keeps the blood vessels entering the penis open longer, allowing more blood to enter. PDE5s are first-line treatment choices for ED. However, the American Urological Society advises that men be offered any ED treatment option after a shared decision-making process.2 

The success rate for Viagra is listed at 50-70%.3 Men with ED who have blood vessel damage from high blood pressure, diabetes, high cholesterol, or smoking may not be as satisfied with their results. Men who have contraindications to using sildenafil, do not want to take a pill, or get unsatisfactory results with sildenafil may choose Trimix to treat their ED.2 

Written by

Leann Poston M.D.
Leann Poston M.D.
Licensed Physician and Medical Content Reviewer
Dr. Leann Poston is a licensed physician in the state of Ohio who holds an M.B.A. and an M. Ed. She is a full-time medical communications writer and educator who writes and researches for Invigor Medical. Dr. Poston lives in the Midwest with her family. She enjoys traveling and hiking. She is an avid technology aficionado and loves trying new things.

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Leann Poston M.D.
Leann Poston M.D.
Licensed Physician and Medical Content Reviewer
Dr. Leann Poston is a licensed physician in the state of Ohio who holds an M.B.A. and an M. Ed. She is a full-time medical communications writer and educator who writes and researches for Invigor Medical. Dr. Poston lives in the Midwest with her family. She enjoys traveling and hiking. She is an avid technology aficionado and loves trying new things.

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