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Everything You Should Know About Trimix: Is There An Antidote?

Last Updated: October 7, 2025
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Key Takeaways
  • Trimix injections deliver ED treatment directly to the penis, offering faster and more targeted results than oral ED pills.
  • Up to 89% of men achieved erections strong enough for intercourse, even when pills like Viagra® or Cialis® failed.
  • Effects usually begin within 5–20 minutes and can last 30 minutes to several hours, depending on dose and response.
  • Priapism (erection lasting over 4 hours) is a medical emergency, but effective antidotes and treatments are available.
  • Trimix may be a reliable second-line option for men resistant to PDE5 inhibitors, supported by strong clinical research.

Trimix

In Stock
As low as $249/Mo
  • Improved erectile function
  • Rapid onset
  • High efficacy (89%-95%)
NAD+ Vial

Trimix offers a promising alternative to traditional ED medications. While oral pills like sildenafil and tadalafil work systematically, Trimix injection delivers ED medication directly to the source

Extensive medical research backs Trimix’s potential. In research, 89% of men taking Trimix injection achieved an erection strong enough for sex. 

Learn more about its potential benefits and an antidote in the case of a prolonged erection (priapism).

What Is Trimix?

Trimix is a type of medication that’s injected directly into the penis to help you get an erection. 

It’s a mix of three different medicines that work together to increase blood flow to your penis, which is key for an erection.

Trimix has three main ingredients:

  • Papaverine: This medicine may help relax the blood vessels in your penis. When these vessels relax, more blood can flow in.
  • Phentolamine: This may also help open up your blood vessels, making it easier for blood to get into your penis and stay there.
  • Alprostadil (Prostaglandin E1): This ingredient may act like a natural substance your body makes. It tells your blood vessels to relax, which may help you get a firm erection.

Studies suggest these three ingredients may work together to make sure enough blood flows into your penis and stays there, creating a strong erection.

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The Potential Success Rate of Trimix

Trimix is known for being very promising. Most men who use Trimix find that it may help them get an erection. 

In research studies, 89% of Trimix users had an erection strong enough for intercourse.

You may usually expect the effect to start pretty quickly, in about 5 to 20 minutes. Once it starts working, the erection can last up to about one hour.

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How Trimix May Help When Other ED Pills Don’t Work

Many men first try pills like sildenafil (brand name: Viagra) or tadalafil (brand name: Cialisis) for their ED. These pills work well for a lot of people, but they don’t work for everyone. 

Trimix is considered a second-line treatment option for those resistant to traditional oral ED drugs. Studies suggest that men taking Trimix after trying an oral ED med increased their erection outcome by 92%.

Trimix Duration

Generally, Trimix-induced erections can last for 30 minutes to several hours. 

The duration of Trimix’s effect can vary among individuals and depends on factors such as dosage, individual response, and level of sexual stimulation. 

Is Trimix Right for You?
See if Trimix is a fit for your sexual performance or ED treatment goals.
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Treating Priapism After a Trimix Injection

Priapism, a prolonged and painful erection lasting longer than four hours, is a medical emergency that requires immediate treatment. 

If priapism occurs after using Trimix, it’s essential to seek medical help promptly. 

Treatment may involve draining blood from the penis using a needle or catheter, administering medications to constrict blood vessels and reduce blood flow to the penis, or, in severe cases, surgical intervention to relieve pressure and prevent tissue damage.

Remember: Always seek immediate medical attention if you have an erection lasting longer than four hours.

Trimix Infographic

Potential Downsides of Trimix

Like any medicine, Trimix has some possible downsides:

  • Injection: The biggest downside for many is that it’s an injection. You have to inject the medicine into the side of your penis, which can be a bit uncomfortable at first. Your doctor or nurse will teach you how to do it safely.
  • Pain or Bruising: Some men might feel a little pain or get a small bruise where they inject the medicine. In a few cases, men 
  • Prolonged Erection (Priapism): In rare cases, an erection can last too long (more than four hours). This is called priapism, and it needs immediate medical attention. We’ll talk more about this below.
  • Scarring: Very rarely, repeated injections can lead to some scarring in the penis.

The Cost of Trimix

The cost of a Trimix shot can vary. It depends on things like where you live, the pharmacy you use, and whether your insurance covers it.

Trimix

In Stock
As low as $249/Mo
  • Improved erectile function
  • Rapid onset
  • High efficacy (89%-95%)
NAD+ Vial

Frequently Asked Questions

Does Trimix lose effectiveness over time?

If not stored properly, Trimix may lose effectiveness. Other factors like heat, light, or air can reduce its potency. 

Follow storage guidelines and be sure to use Trimix within its expiration date for optimal results.

Consulting with a healthcare provider if Trimix appears to be less effective can help identify potential causes and adjust treatment as needed.

What is the downside of Trimix?

While Trimix is effective for many individuals with ED, there are potential downsides to consider. These may include the need for self-injection, which can be intimidating or uncomfortable for some. 

Additionally, there’s a risk of side effects such as pain at the injection site, bruising, or scarring of penile tissue. 

Rare but serious complications like priapism can also occur. It’s important to discuss potential risks and benefits with a healthcare provider to determine if Trimix is the right treatment option for you.

Written by

Derek Berkey
Derek Berkey
CEO, Invigor Medical | Science-Based Wellness Expert
Derek Berkey is the Chief Executive Officer of Invigor Medical, a telehealth company specializing in weight management, sexual health, and healthy aging. He serves as an author and reviewer, ensuring all content is grounded in science-based, patient‑centered insight.

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Every article on Invigor Medical is reviewed by licensed medical professionals to ensure accuracy, clarity, and clinical relevance. Our editorial team works closely with practitioners to verify that content reflects current research, guidelines, and best practices.
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Medical treatments discussed on this site may not be appropriate for everyone. All medications require a prescription from a licensed healthcare provider following an appropriate telehealth consultation, and treatment decisions should be made on an individual basis.
Derek Berkey
Derek Berkey
CEO, Invigor Medical | Science-Based Wellness Expert
Derek Berkey is the Chief Executive Officer of Invigor Medical, a telehealth company specializing in weight management, sexual health, and healthy aging. He serves as an author and reviewer, ensuring all content is grounded in science-based, patient‑centered insight.

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